Pandura 2mg Tablet

Uses of

How does

Side Effects of

• The most common side effects include CNS depression, such as drowsiness and ataxia.
• Behavior problems, abnormal eye movements, aphonia, tremors, vertigo, depression, amnesia, hallucinations, increased libido, insomnia, and palpitations may also occur.

Quick Suggestions:

• The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
• It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
• Avoid consuming alcohol as it may increase dizziness and drowsiness.
• Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
• Inform your doctor if you experience worsen anxiety, depression angry, or violent behavior and mania while taking this medicine.
• Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.

Indication

• Lennox-Gastaut Syndrome (petit mal variant): Pandura 2 Tablet is indicated alone or as an adjunct in the treatment of this syndrome, which includes akinetic and myoclonic seizures.
• Absence Seizures (Petit Mal): It may be indicated in patients with absence seizures who have not responded to succinimides.
• Panic Disorder: It is indicated for the treatment of panic disorder, with or without agoraphobia. Panic disorder is characterized by unexpected panic attacks and associated worry about having more attacks.

Pharmacology

• Benzodiazepine Properties: Clonazepam, the active ingredient, has typical benzodiazepine properties, including anticonvulsant, sedative, muscle relaxant, and anti-anxiety effects.
• Mechanism of Action: It increases GABAergic neurotransmission in inhibitory synapses, leading to an increase in the effect of GABA, an inhibitory neurotransmitter, on the post-synaptic transmembrane chloride flux.
• Effect on Epilepsy: Clonazepam has been shown to quickly inhibit various types of paroxysmal activities in animal studies and human EEG studies, making it effective for generalized and focal epilepsy.

Dosage & Administration of

• Adults: The initial dose for seizure disorders should not exceed 1.5 mg/day, with incremental increases until seizures are controlled or side effects prevent further increases. The maximum daily dose is 20 mg.
• Panic Disorder in Adults: The initial dose is 0.25 mg given in two divided doses, with an increase to 1 mg/day for most patients after 3 days.
• Pediatric Patients: Dosing for infants and children up to 10 years old or 30 kg should be between 0.01 and 0.03 mg/kg/day, not to exceed 0.05 mg/kg/day, given in two or three divided doses.

Interaction

Clonazepam does not appear to affect the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. Its effects on other drug metabolisms have not been studied.

Contraindications

• Pandura 2 Tablet should not be used in patients with hypersensitivity to benzodiazepines or those with significant liver disease.
• It is contraindicated in acute narrow-angle glaucoma but may be used in open-angle glaucoma with appropriate therapy.

Pregnancy & Lactation

• Use in pregnancy should be considered if benefits outweigh potential risks. Breastfeeding is not recommended while using Clonazepam.
• Caution is advised when used in patients with multiple seizure disorders, and its concomitant use with valproic acid may lead to absence status.

Precaution & Warnings:

• Use in pregnancy should be considered if benefits outweigh potential risks. Breastfeeding is not recommended while using Clonazepam.
• Caution is advised when used in patients with multiple seizure disorders, and its concomitant use with valproic acid may lead to absence status.

Storage Conditions

Store in a dry place away from light and heat, and keep it out of the reach of children.